National Amateur Radio Organization of People's Republic of China.
1I crack't out laughing when I heard tell o' such nonsense.
2How these proteins interact to assemble functional CRAC channels has remained uncertain.
3CRAC channels were visualized as fluorescent puncta in total internal reflection microscopy.
4The latter defect emphasizes an important role of CRAC channels in tooth development.
5This effect is reversed when cells are treated with a CRAC channel inhibitor.
6The identity and activation mechanism of CRAC channels at a molecular level are unknown.
7MIC channels differ from CRAC channels in several critical respects.
8This hydrophobic gating mechanism has implications for CRAC channel function, pharmacology and disease-causing mutations.
9We propose that Orai1 is an essential component or regulator of the CRAC channel complex.
10Crac de Chevaliers was bombed by government fighter jets after rebel snipers took up position inside.
11Defects in CRAC channel function are associated with serious human diseases such as immunodeficiency and auto-immunity.
12CRAC channels are composed of ORAI1 proteins located in the plasma membrane, which form its ion-conducting pore.
13Pore helix rotation by STIM1 also explains the dynamic coupling between CRAC channel gating and ion selectivity.
14We recently used a two-pronged genetic approach to identify Orai1 as the pore subunit of the CRAC channel.
15Here we review recent work addressing CRAC channel regulation, pore properties, and the search for CRAC channel genes.
16These changes in ion selectivity provide strong evidence that Orai1 is a pore subunit of the CRAC channel.