In all vaccinated but none control animals, E. ruminantium-induced IFN- gamma secretion was observed in 24 h stimulated blood.

Nevertheless, DR(+)IC had reduced capacity to capture antigens and elicited poor proliferation and interferon- gamma secretion by T-lymphocytes.

Ag-specific IFN- gamma secretion was detectable in all LSA-3-immunized animals in response to the LSA-3-derived Ag.

The suppression of joint inflammation by rolipram was associated with the inhibition of the OVA-specific proliferative responses of spleen cells and IFN- gamma secretion.

Treg-induced inhibition of IFN- gamma secretion could be partially blocked by neutralizing PD-1 and PD-L1 antibodies specifically in HCC patients.

Triggering of NTB-A with monoclonal antibodies in the absence of CD28 signals leads to T cell proliferation and interferon- gamma secretion but not interleukin-4.

Finally, DC activated with CD40L and IL-1beta induce higher levels of IFN- gamma secretion by T cells compared with DC activated with CD40L alone.

Here, we demonstrate that blocking the interaction between CD55 on monocytes and CD97 on T cells leads to inhibition of proliferation and interferon- gamma secretion.