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Their ability to readily manipulate the native genomicloci is particularly advantageous.
2
However, processing different databases and searching among millions of genomicloci is not trivial.
3
Currently miRBase is their primary repository, providing annotations of primary sequences, precursors and probable genomicloci.
4
Pseudo-polyploidy at relevant genomicloci sets the stage for gaining additional mutations at the locus of interest.
5
This study was aimed at identifying the genomicloci linked to exercise participation in males and females.
6
Conclusions: We show that LID vectors represent a promising tool for the transfer of complete genomicloci.
7
The matching reads were counted and further compared to the known sequences of the full wildtype and mutant genomicloci.
8
We apply the approach to a variety of genomicloci in five hPSC lines cultured using both feeder and feeder-free conditions.
9
Combined with fluorescence in situ hybridization, replication origins can be mapped in genomicloci including repetitive DNA and a single-copy gene.
10
A number of approaches for Cas9-mediated transcriptional activation have recently been developed, allowing target genes to be overexpressed from their endogenous genomicloci.
11
Mechanistic roles for many lncRNAs are poorly understood, in part because their direct interactions with genomicloci and proteins are difficult to assess.
12
Genome analysis of diverse human populations has contributed to the identification of novel genomicloci for diseases of major clinical and public health impact.
13
As a result, there is increasing interest in creating 'genomically' humanized mouse models, in which entire human genomicloci are transferred into the mouse genome.
14
Conclusions: fcScan is ideal for detecting cis-regulatory modules of transcription factor binding sites with a specific grammar as well as genomicloci enriched for mutations.
15
In addition, this system is also applied to loss-of-function mutations in pain-related genes and knockin of reporter genes or loxP tags at pain-related genomicloci.
16
NATsDB supports interactive graphical display of the alignment of all supporting EST and mRNA transcripts of the SA and NOB genes to the genomicloci.