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Genetically and clinically heterogeneous group of neurodegenerative disorders characterized by progressive spasticity and hyperreflexia of the lower limbs.
Autosomal dominant hereditaryspasticparaplegia is genetically heterogeneous, with at least five loci identified by linkage analysis.
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Understanding the cellular functions of spatacsin will allow deciphering mechanisms of motor cortex dysfunction in autosomal-recessive hereditaryspasticparaplegia.
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SPG13, an autosomal dominant form of pure hereditaryspasticparaplegia, was recently mapped to chromosome 2q24-34 in a French family.
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Recently, mutations in spastin were identified in SPG4, the most common locus for dominant hereditaryspasticparaplegia that was previously mapped to chromosome 2p22.
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Purpose of review: Hereditaryspasticparaplegias are a genetically heterogeneous group of diseases.
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Hereditaryspasticparaplegia is a spastic gait disorder that arises from degeneration of corticospinal axons.
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Hereditaryspasticparaplegias are a group of inherited motor neuron diseases characterized by progressive paraparesis and spasticity.
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Hereditaryspasticparaplegias are a heterogeneous group of neurodegenerative disorders, clinically classified in pure and complex forms.
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The hereditaryspasticparaplegias are an expanding and heterogeneous group of disorders characterized by spasticity in the lower limbs.