By generating mouse models expressing the human genes, species differences in heterocyclicamine metabolism can be addressed.
2
Therefore, the human response to PhIP and other heterocyclicamine exposure may not be accurately reflected in the laboratory rodent.
3
Differences in the metabolism of the heterocyclicamine PhIP were observed between wild-type and hCYP1A2 mice.
4
Meat Barbecuing is known to generate potentially cancer-causing chemicals known as heterocyclicamines.
5
This study only provides weak support for a similar association with meat heterocyclicamines.
6
Background: Red meat intake has been associated with risk of colorectal cancer, potentially mediated through heterocyclicamines.
7
The results from this study indicate that breast milk is a route of exposure of the newborn to heterocyclicamines.
8
These high-temperature cooking methods are thought to be surrogates for mutagens and carcinogens produced in meat and fish, eg heterocyclicamines or polycyclic hydrocarbons.