Volunteer reserve branch of Denmark's military.
1Their cellular localization was studied by immunofluorescence with antibodies raised against Hjv and TfR2.
2Hjv and TfR2 are present in human and rat liver and in primary human hepatocytes.
3We investigated the expression and cellular localization of Hjv and TfR2 in rat and human liver.
4The normal function of HJV is unknown.
5The localization of Hjv and TfR2 at the same membrane domain renders a functional interaction of these two proteins in iron homeostasis possible.
6HJV has also been demonstrated to bind to neogenin, but it is not known whether this interaction has a role in regulating hepcidin expression.
7Juvenile hemochromatosis is a rare but the most severe form of hereditary hemochromatosis which develops due to mutations in the HJV or HAMP genes.