Their cellular localization was studied by immunofluorescence with antibodies raised against Hjv and TfR2.

Hjv and TfR2 are present in human and rat liver and in primary human hepatocytes.

We investigated the expression and cellular localization of Hjv and TfR2 in rat and human liver.

The normal function of HJV is unknown.

The localization of Hjv and TfR2 at the same membrane domain renders a functional interaction of these two proteins in iron homeostasis possible.

HJV has also been demonstrated to bind to neogenin, but it is not known whether this interaction has a role in regulating hepcidin expression.

Juvenile hemochromatosis is a rare but the most severe form of hereditary hemochromatosis which develops due to mutations in the HJV or HAMP genes.