The secreted version of the human Ig transgene has no such effect.

We have isolated peptide-specific antibodies from pooled normal human Ig preparations.

We have mapped the transcriptional and chromatin landscape of the human Ig heavy-chain locus to investigate the effect these activities have on CSR.

Herein, we examine the use of human DIR gene segments by cross-breeding the human Ig heavy chain minilocus pHC1 transgenic mice and TdT-deficient mice.