In humantumours, DIAPH3 down-regulation was associated with aggressive or metastatic disease.
2
In humantumours, a number of different proteases also correlate with metastatic potential.
3
Recent evidence suggests that Runt-related transcription factors play a role in different humantumours.
4
The tumour suppressor gene TP53 is the most frequently mutated gene in humantumours.
5
Most humantumours are heterogeneous, composed of cellular clones with different properties present at variable frequencies.
6
Expression of class I HLA antigen has been shown to be reduced in a number of humantumours.
7
Here we capitalize on the availability of multi-platform data on thousands of humantumours to build integrative models of DNA methylation.
8
While tumour cells migrate through tissues using diverse strategies, the signalling networks controlling such behaviours in humantumours are poorly understood.
9
The bcl-2 protein is found to be over-expressed in many types of humantumours and is a potent inhibitor of apoptosis.
10
Preliminary data from Phase I clinical trials indicate that cis CA-4 may also be effective in targeting the vasculature of humantumours.
11
This suggests that the presence of somatostatin receptors on humantumours does not automatically imply a beneficial effect of somatostatin analogue therapy.
12
An increasing number of scientific reports have described evidence for a polyomavirus, simian virus 40, in a highly select group of humantumours.
13
We have used a polyclonal antibody to recombinant human TS to establish a silver-enhanced immunogold staining method to localize TS in humantumours.
14
Humantumour cell lines with acquired resistance to TS inhibitors owing to increased levels of TS were used to confirm the specificity of immunostaining.
15
The TP53 mutation patterns induced by these mutagens in the HIMA corresponded to those found in humantumours from patients exposed to these mutagens.
16
TP53 mutation spectra generated can be compared with those of humantumours recorded in the International Agency for Research on Cancer TP53 mutation database.