The mechanism by which H. pylori induces Shh is unknown.

We hypothesize that NFkB mediates H. pylori- induced Shh.

Results: Within 2 days of infection, H. pylori induced Shh expression within parietal cells of Shh::GFP mice.

H. pylori induces Shh expression from the parietal cells, a response mediated via activation of NFkB signaling.

H. pylori infection of gastric organoids induced Shh expression; a response that was blocked by inhibiting NFkB signaling and correlated with IkB degradation.

Ablation of the single Gnas gene in anatomically distinct progenitors in mice is sufficient to induce Shh-associated medulloblastomas, which recapitulate their human counterparts.