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1
But the long-term health effects of the nicotine devices remain
largely
unknown
.
2
However, the mechanisms underlying the process of transendothelial recruitment remain
largely
unknown
.
3
Despite considerable efforts, its genetic basis and cellular mechanisms remain
largely
unknown
.
4
However, their functions and mechanisms in tumorigenesis and development remain
largely
unknown
.
5
However, its potential functions and underlying mechanisms in hepatocarcinogenesis remain
largely
unknown
.
6
However, its biological activities and its role in infection are
largely
unknown
.
7
However, which components of particulate matter may be causative remains
largely
unknown
.
8
However, it remains
largely
unknown
whether such combination therapy affects the pancreas.
9
However, the role of neddylation in antiviral innate immunity remain
largely
unknown
.
10
However, how they cross-regulate each other during this process remains
largely
unknown
.
11
However, the molecular factors involved in this plasticity have remained
largely
unknown
.
12
However, the functions and mechanisms of virulence factor localization remain
largely
unknown
.
13
However, the evolutionary mechanisms underlying gene retention after WGD remain
largely
unknown
.
14
However, the function and the physiological substrates of BACE1 remain
largely
unknown
.
15
However, the mechanism of bovine sperm functional regulation is still
largely
unknown
.
16
In contrast, factors that control the expression of lncRNAs remain
largely
unknown
.
largely
unknown
largely