Significados de mdr en inglés

The mammalian mdr gene family comprises a small number of closely related genes.

Expression levels of each mdr gene are dramatically different in various mouse tissues.

Each of the mdr genes has a specific RNA transcript pattern.

Tet could downregulate the level of mdr-1 gene and decrease the expression of P-gp.

In addition, a number of strategies aimed at reversing the mdr phenotype are under study.

H17 proved to be more active than cyclosporine A as a known strong mdr modulator.

We have identified distinct mdr gene transcripts encoded by three separate mdr genes in the mouse.

In this report, we characterize a second member of the mdr gene family which we designated mdr2.

These results should be considered in relation to understanding the normal physiological function of the mdr multigene family.

The mdr-1 level was measured in 44 biopsies from 19 patients.

Our results demonstrate that overexpression of a single member of the mdr group is sufficient to confer drug resistance.

It was previously demonstrated that multidrug-resistant Chinese hamster cell lines contain an amplified, transcriptionally active DNA sequence designated mdr.

However, the direct relationship, if any, of this new member of the mdr family to multidrug resistance remains to be established.

Multidrug resistance in mammalian tumor cells is associated with the overexpression of mdr genes encoding P-glycoproteins, which function as drug efflux pumps.

Alternatively, some groups are investigating transfecting the mdr gene into bone marrow cells to reduce the sensitivity of these cells to cytotoxic agents.

In these cell lines high levels of resistance are frequently associated with amplification and overexpression of a small group of genes termed mdr or gp170.