Significados de metastatic crc en inglés

Conclusion: Isolating and characterizing CTCs from patients with metastatic CRC is feasible.

Experimental design: We conducted a phase II, multi-institutional study of the combination in metastatic CRC patients.

Chemotherapeutic agents serve as the historical first line of defense in the treatment of metastatic CRC.

Methods: Patients who had been rechallenged with FOX were identified from the South Australian metastatic CRC database.

Increased survival among patients with metastatic CRC will likely result in an increased incidence of brain metastases.

Therefore, the authors recommend the use of more tolerable infusional 5-FU-based regimens in the treatment of metastatic CRC.

Patients and methods: Fifty patients with metastatic CRC contributed 50 mL of blood at treatment initiation and disease evaluation timepoints.

In addition, our results suggest that regorafenib displays antimetastatic activity, which may contribute to its efficacy in patients with metastatic CRC.

In a subset analysis, DCC immunoreactivity was compared between metastatic CRC and the corresponding primary tumors and regional lymph node metastases.

These results underscore the role of latency in the evolutionary path of metastatic CRC and may have implications for future treatment options.

Others have reported a worsened outlook for metastatic CRC patients with KRAS mutation and a higher likelihood of metastatic disease to the lungs.

The aim of our study was to identify a microRNA signature for metastatic CRC that could predict and differentiate metastatic target organ localization.

Increased frequencies of tumor-reactive DP TIL in metastatic CRC suggest that these cells play a role in the metastatic process of this cancer.

Low levels of DP TIL were found in most CRC samples and in normal colonic mucosa, but these cells were higher in metastatic CRC.

Hence, a consensus meeting was held in Hong Kong in December 2012 to develop Asia-specific guidelines for the management of metastatic CRC (mCRC).

However, the clinical prognosis of metastatic CRCs is still poor, and novel drugs are currently assessed with respect to their efficacies in patients with CRCs.