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These data indicate the mitochondrialdivision dynamin directly regulates mitochondrial outer membrane permeabilization independent of Drp1-mediated division.
2
We addressed how division proteins regulate apoptosis using inhibitors of mitochondrialdivision identified in a chemical screen.
3
The most efficacious inhibitor, mdivi-1 (for mitochondrialdivision inhibitor) attenuates mitochondrialdivision in yeast and mammalian cells by selectively inhibiting the mitochondrialdivision dynamin.
4
Mitochondrialdivision promotes apoptosis by an unknown mechanism.