Introduction: Both nonclassical and intermediate monocytes have been implicated in different inflammatory conditions.

Both the nonclassical and intermediate subsets were negatively correlated with the platelet counts.

The function of the other, nonclassical class I molecules in man is controversial.

These nonclassical monocytes showed a more activated phenotype in pregnant ATP-infused rats only.

ATP infusion increased the percentage of nonclassical monocytes in pregnant rats even further but not in nonpregnant rats.

A recent study highlights the importance of nonclassical end joining mechanisms in the formation of these oncogenic DNA rearrangements.

HLA-G is a nonclassical MHC molecule with highly limited tissue distribution that has been attributed chiefly immune regulatory functions.

Changes in classical and nonclassical HLA class I antigen and NK cell-activating ligand expression have been identified in malignant lesions.

Compared with controls, the frequency of nonclassical monocytes was significantly increased in patients with active ITP but decreased after complete remission.

In rats, we also found lower percentages of classical monocytes and higher percentages of nonclassical monocytes in pregnant versus nonpregnant rats.

Here, using molecular dynamic simulations and docking, we studied the binding of known inhibitors to representative members of classical and nonclassical calpains.

DFT calculations show that the reaction proceeds through a nonclassical carbocation-anion pair, which is crucial for the low activation barrier and enantiospecificity.

A protective role against NK cells equipped of suitable inhibitory receptors has been proposed for nonclassical HLA-class I molecules including HLA-E and HLA-G.

As none of the classical secretion systems appears to be involved, this type of secretion was referred to as "nonclassical protein secretion."

These results, together with advances in our understanding of nonclassical MHC class I presentation, reveal the impact of pathogen biology on host immunity to infection.

The nonclassical subset showed the highest capability of promoting platelet reactive T-cell proliferation and significantly promoted the secretion of interferon γ among the 3 subsets.