Longitudinal studies with paired biopsies will assist in refining the Ordinal Regression Index.

In clustering analysis, almost all paired biopsies from the same tumors joined each other.

Clinically significant discrepancies were present in only 6% of paired biopsies.

Paired biopsies at baseline, at EOT and at long-term were available in 42 patients.

Paired biopsies were optional to evaluate pathway modulation.