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We identified cDNAs encoding an active mono-oxygenase that is highly homologous to mammalian PHM.

PHM is the rate-limiting enzyme for C-terminal alpha-amidation, a specific and necessary modification of secretory peptides.

Horton Inc DHI.N and rival PulteGroup Inc PHM.N reported quarterly profits in April that topped estimates.

These deficits were partially reversed within 24 h by a single PHM induction in the adult stage.

The mechanistic and structural insight gained from the PHM structures can be directly extended to dopamine beta-monooxygenase.