1
A synthesis of the ABC-rings of the polyketide natural product hexacyclinic acid has been achieved.
2
The two essential structural components of macrolide antibiotics are the polyketide aglycone and the appended sugars.
3
Feeding experiments using (13)C-labeled acetate were carried out to confirm that the angucycline core is indeed polyketide-derived.
4
The present study confirmed the presence of the unusual pathway in the biosynthesis of a hybrid peptide-polyketide natural product.
5
This result clearly indicated that macrolactone formation proceeds 15-OH oxidation since the linear polyketide is not a substrate for SpnJ.