Secretion of pulmonarysurfactant in the alveoli of the lungs is essential to maintain lung function.
2
Mixtures of PxB and pulmonarysurfactant show antimicrobial effects in neonatal rabbits and prevent systemic spreading of E. coli.
3
In neonatal pneumonia, the surface activity of pulmonarysurfactant is impaired and microorganisms may invade by passing the air-liquid interface.
4
Recent studies have demonstrated that pulmonarysurfactant protein (SP)-A plays a potential role in modifying inflammation and immune function.
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However, it is vital that corticosteroids delivered via the lungs not interfere with surface activity of the pulmonarysurfactant lining layer.
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This study has implications in the fundamental understanding of surface thermodynamics as well as applications such as self-assembled monolayers and pulmonarysurfactant biophysics.
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We demonstrated that the increased absorption resulted from DPPC that had permeation enhancer properties even though it was abundantly present locally in pulmonarysurfactant.
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The acute respiratory distress syndrome (ARDS) is characterized by arterial hypoxemia accompanied by severe inflammation and alterations to the pulmonarysurfactant system.
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Inhaled NP penetrate deep pulmonary structures in which they first interact with the pulmonarysurfactant (PS) lining at the alveolar air-water interface.
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Objective: Our goal was to examine the effects of oligohydramnios and cervical cord transection on fetal lung development, pulmonarysurfactant, and lung mechanics in rabbits.
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Hydrophobic protein of 6,000 and 14,000 daltons was isolated from mammalian pulmonarysurfactant obtained from canine, human, and bovine alveolar lavage material.
12
Pulmonarysurfactant acts at this air-liquid interface.
13
Pulmonarysurfactant dysfunction may significantly contribute to small airway obstruction during the asthmatic response, but neither its exact role nor its regulation is clear.
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It has been reported that pulmonarysurfactants or their components could facilitate the uptake of small interfering RNA (siRNA) into the lung epithelial cells.
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Pulmonarysurfactant (PS) dysfunction because of the leakage of serum proteins into the alveolar space could be an operative pathogenesis in acute respiratory distress syndrome.