Conclusions: We report details on possible PTU-associated birth defects.
2
The method was successfully applied for the determination of PTU and MTZ in real samples.
3
SCr returned to baseline within 2 weeks of methimazole discontinuation, and the patient was subsequently managed on PTU.
4
After subtotal thyroidectomy with discontinuance of PTU the patient remained asymptomatic for the last two and half years.
5
These findings indicate that the patient developed autoimmune neutropenia by producing opsonic antineutrophil antibodies in association with the PTU therapy.