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1 Individual self- reactive T cells have been discovered in both humans and mice.
2 The presence of type B reactive T cells should be considered in autoimmunity.
3 Stably maintained clonotypes included T cells having high-avidity TCR such as virus- reactive T cells.
4 Peripheral tolerance is crucial for avoiding activation of self- reactive T cells to tissue-restricted antigens.
5 Tumor- reactive T lymphocytes can promote the regression of established tumors.
6 The recall cell-division response was also defective in SEA- reactive T cells isolated from TCDD-exposed mice.
7 RAPA interfered with the deletion of potentially self- reactive T cells that occurs in thymic development.
8 T-cell-mediated dominant control of self- reactive T cells is one mechanism for maintaining immunologic self tolerance.
9 Regulatory T cells control the reactivity of potentially harmful, self- reactive T cells and prevent autoimmune diseases.
10 Anti-CTLA-4 treatment resulted in increased numbers of SEB- reactive T cells and blockade of subsequent tolerance induction.
11 Tumor- reactive T cells become unresponsive in advanced tumors.
12 Regulatory T (Treg) cells suppress inflammatory immune responses and autoimmunity caused by self- reactive T cells.
13 Atorvastatin inhibited gluten-induced proliferation and specific cytokine production of human intestinal gluten- reactive T cell clones and lines.
14 In some families the highest number of MBP peptide reactive T cells were found among unaffected family members.
15 This allowed us to quantify the activation requirements of a representative polyclonal yet monospecific tumor- reactive T cell population.
16 Self- reactive T cells escaped to negative selection are then controlled by natural T regulatory (Treg) cells.
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