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1
Previous studies have emphasised poor long-term outcomes for those with
severe
CAA
.
2
However, logistic regression analysis showed low NEP levels to be a significant independent predictor of moderate to
severe
CAA
.
3
We suggest that it might also be applicable to quantifying
severe
CAA
and related microvascular degenerative changes in patients with AD.
4
Colinearity of epsilon4 with the presence of moderate to
severe
CAA
precluded assessment of the independence of this association from NEP levels.
5
Thirty of 117 brains (25.6%) showed moderate to
severe
CAA
affecting the cerebral vessels in one or more cortical regions.
severe
caa
severe