Significados de smo en inglés

We developed methods for culture of cardiocytes from zebrafish embryos and found that, even in culture, cells from smo continue to beat relatively slowly.

The peculiarity of smo....

Thus, the differential phosphorylation of Smo mediates the thresholds of Hh activity.

In addition, little is known about whether ubiquitination is involved in Smo regulation.

Smo inhibitor particularly blocked the formation of hypertrophic chondrocytes and collagen type X expression.

Moreover, we showed that Smurf-mediated Patched ubiquitination depends on Smo activity in wing discs.

Here, we identify a novel feedback mechanism that regulates Smo through the Fu-Cos2 complex.

Furthermore, these data support rational combinations of hypomethylating agents with SMO antagonists in clinical trials.

The activation of Smo appears to be one of the most important events in Hh signaling.

We show that SANTs and SAG exert opposite effects on Smo activity by regulating protein conformation.

A longstanding question is how Ptc inhibits Smo and how such inhibition is relieved by Hh stimulation.

Endogenous Smo accumulated upon ESCRT-III inactivation is highly activated, which is induced by phosphorylation but not sumoylation.

Furthermore, we find that the levels of Smo cell-surface expression and activity correlate with its levels of phosphorylation.

Mutating these serine residues attenuates the ability of Smo to transduce high level Hh signaling activity in vivo.

Two additional cell lines both having one methylated SMO allele and expressing mutant SMO did not express GLI3.

In summary, our study reveals a novel cell survival mechanism in which SMO stabilizes and protects TRAF6 from degradation.