Significados de underlying als en inglés

However, as mutations underlying ALS pathogenesis have not yet been identified, it remains difficult to establish useful models of SALS.

These findings might be relevant for understanding the pathophysiological processes underlying ALS and thus could contribute to the development of new therapeutic strategies.

Gaining a better understanding of the role(s) that FUS and TDP43 play in transcription-associated DNA damage could shed light on the mechanisms underlying ALS pathogenesis.