Furthermore, we discuss how AdRCs facilitate the interplay between viral and cellular machineries and hijack cellular functions to promote viralgenomereplication and expression.
2
Double-stranded RNA intermediates generated during viralgenomereplication are recognised by host innate immune sensors in the cytoplasm, activating the strongly antiviral interferon gene programme.
3
Viralgenomereplication was unaffected, and inhibition could be elicited late in infection and persisted upon drug removal.