Muscle strength values were adjusted for the influence of body height and body weight using an allometric scaling procedure.

The most successful allometric scaling method yielded clearance predictions that were, on average, within 80% of actual values.

A two-compartment model with one transit compartment prior to first-order absorption and allometric scaling by body weight on clearance and volume terms was selected.

The predicted human oral pharmacokinetic (PK) profile was constructed using allometric scaling of plasma clearance and volume of distribution in the terminal phase from animals.