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Combination treatment with surgical castration and systemic cav-1 antibody dramatically reduced the number of experimental metastases.

These experimental data suggest a causal association of secreted cav-1 and prostate cancer growth and progression.

Below the cardinal vein (cav) is the prorenal duct (wd) and a segmental prorenal canal (st).

Resveratrol treatment alleviated the hyperpermeability and the overexpression of cav-1 induced by high glucose in a dose-dependent manner.

CAV is the main risk factor for a reduced long-term graft survival.