The mitochondrial sirtuin SIRT3 regulates metabolic homeostasis during fasting and calorie restriction.

The science of calorie restriction just got a lot more complicated.

Objectives: To evaluate whether calorie restriction increases cigarette smoking in humans.

This was almost completely nullified by SGLT2 inhibition and calorie restriction.

Sometimes calorie restriction does improve longevity -and sometimes it doesn't.

Other accounts described calorie restriction having very different effects in different strains of mice.

Cons: Severe calorie restriction and associated hunger, even for just two days is tough.

Conclusions: RYGB ameliorates glucose and lipid metabolism accompanied by weight loss and calorie restriction.

In conclusion, calorie restriction and exercise-induced weight loss both decrease IMAT and VAT volumes.

Humanity's best bet for extreme lifespan extension is likely to be extreme calorie restriction.

A key outcome of calorie restriction, the researchers figure, is the disappearance of fat.

Cultivation methods used to investigate microbial calorie restriction often result in carbon and energy starvation.

Conclusions: Severe calorie restriction promotes a reduction in adipose tissue and plasma levels of RBP4.

Importantly, these findings occurred in the absence of any calorie restriction and significant weight loss.

SGLT2 inhibition as well as calorie restriction almost completely eliminated citrate accumulation in the cortex.

Luckily, researchers are coming closer to finding a way to mimic the effects of calorie restriction.