Significados de camptothecin em inglês

A fourth hit, 9-methoxy-camptothecin, was identified by screening the natural compound library in the absence of verapamil.

The chemical stabilities of camptothecin and the ring-opened form in aqueous solutions, in plasma and after methanolic extraction, were investigated.

Irinotecan is a semisynthetic analogue of the natural alkaloid camptothecin which prevents DNA from unwinding by inhibition of topoisomerase I.

Knowledge of the structure-activity relationships of the parent compound camptothecin has led to the development of effective soluble analogues with manageable toxicities.

We report here that the release mechanism of free camptothecin from self-assembling drug amphiphiles can be regulated by use of different linker groups.

Colony formation studies suggest that it is weakly cytotoxic, but that its mechanism of toxicity differs from that of camptothecin and its derivatives.

LPA rescued cells from apoptosis when applied up to 1 hour after camptothecin treatment or 2 hours after irradiation.

Subsequent analyses of these tah mutants identified 9 genes whose function suppresses the cytotoxic action of camptothecin and Top1T722A.

The release of insulin and chemotherapeutic camptothecin was also observed to be released in a controlled manner over the course of 180 min in vitro.

Meanwhile, in 10 lM concentration, both compounds 24 and 25 showed significant protection against apoptosis in camptothecin-induced Jurkat T cells system.

At a fractional effect of 0.5, all three agents were synergistic with either camptothecin or gemcitabine in Mz-ChA-1 cells in vitro.

Among new drugs with activity in patients with SCLC brain metastases, camptothecin analog topotecan is one of the most promising with a 52% RR.

This observation may have important clinical implications for future development of novel camptothecins.

Camptothecin reversibly stabilizes the covalent enzyme-DNA intermediate by inhibiting DNA religation.

Camptothecin, a plant secondary metabolite is widely used in the treatment of metastatic breast cancer and lymphoma.

The company's other cancer drug based on the Tocosol technology is Camptothecin, which is currently in an early-stage trial.