Ainda não temos significados para "cause lethality".
1Targeted deletion of VGLUT1 in mice causes lethality in the third postnatal week.
2The underlying mechanisms causing lethality and person-to-person variation in outcome remain incompletely explained.
3We also show that early widespread expression of the fusion protein disrupts normal embryogenesis, causing lethality.
4We developed and characterized a conditional knock-out mouse model and found that GSKIP deficiency caused lethality at birth.
5A large number of dominant mutants have been generated in the fission yeast cdc2 gene, causing lethality when expressed in wild-type cells.