Significados de chromosome instability em inglês

Background & aims: Many different types of cancer cells have chromosome instability.

Centrosomes organize the bipolar mitotic spindle, and centrosomal defects cause chromosome instability.

The literature claiming increased chromosome instability in TGCT patients is reviewed.

Therefore, it appears that the main mechanism of tumour progression stems from chromosome instability.

The pathogenesis of PDAC is partly attributable to intrinsic chromosome instability and extrinsic inflammation activation.

Based on current knowledge of chromosome instability, the nature of distamycin A-inducible fragile sites is discussed.

Background: Mutations in mitotic checkpoint genes have been detected in several human cancers, which exhibit chromosome instability.

Some cancer cells show a weakened checkpoint signaling system that may contribute to chromosome instability in tumors.

The dramatic chromosome instability in certain tumors might reflect a synergy of spindle checkpoint defects with hypoxic conditions.

In human HCC tissues, high levels of nuclear YAP correlated with increased chromosome instability gene expression patterns and aneuploidy.

Taken together, these data indicate that HCV infection inhibits multiple DNA repair processes to potentiate chromosome instability in both monocytes and hepatocytes.

Several studies have found that these interstitial telomeric repeat sequences can promote chromosome instability in rodent cells, either spontaneously or following ionizing radiation.

Conclusions: By analyzing cell lines, genetically modified mice, and HCC tissues, we found that YAP cooperates with FOXM1 to contribute to chromosome instability.

The oncogenic transcription factor FoxM1 plays a vital role in cell cycle progression, is activated in numerous human malignancies, and is linked to chromosome instability.

This cohesion fatigue, resulting in unscheduled chromatid separation in cells delayed at metaphase, constitutes a previously overlooked source for chromosome instability in mitosis and meiosis.

Chromosome instability and DNA repair defects are the cellular characteristics used for the clinical diagnosis.