1
Its central feature, a six-stranded coiled coil, is also novel for proteins.
2
We generated a mutant Sycp2 allele in mice that lacks the coiled coil domain.
3
The leucines adopt a ladder-like conformation around the 2-fold axis of the coiled coil.
4
The two GAT domains are connected by an antiparallel coiled coil, forming a 90 A-long barbell-like structure.
5
An evolutionarily conserved coiled coil domain in SYCP2 is required for binding to SYCP3.
6
Initially, a model is created consisting of C alpha atoms only, representing an idealized coiled coil with infinite pitch.
7
Here we show that changes in registration between the two helices of the coiled coil can perform this function.
8
Assembly is mediated by the conserved N-terminal architecture comprising a RING domain, a Bbox domain, and a coiled coil.
9
We identified and evaluated the malaria vaccine potential of fragments of several malaria antigens containing a-helical coiled coil protein motifs.
10
We describe a procedure for designing proteins with backbones produced by varying the parameters in the Crick coiled coil-generating equations.
11
This phosphorylation is mediated by the kinase ROCK (Rho-associated coiled coil-containing protein kinase) I subsequently to Rho activation.
12
Each C helix shows especially prominent contacts with one of three symmetry-related, hydrophobic cavities on the surface of the coiled coil.
13
Most of the amino-terminal one-third of sigma 1 sequence is predicted to form an alpha-helical coiled coil like that of myosin.
14
The final structures show similar crossing angles of the coiled coil, although this was not used as a restraint in the calculation.
15
We locked the coiled coil at three specific registrations using oxidation to disulfides of paired cysteine residues introduced into the two helices.
16
Central and carboxy terminal coiled coil domains were found to mediate binding of YlfA and YlfB to themselves and to each other.
