Vision relies on photoactivation of visual pigments in rod and conephotoreceptor cells of the retina.
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This confirms that AO flood imaging provides reliable estimates of pericentral conephotoreceptor distribution in normal subjects.
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Furthermore, cpfl1 conephotoreceptor migration during early postnatal development was delayed significantly compared with the corresponding wild-type retina.
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Purpose: An often overlooked prerequisite to conephotoreceptor gene therapy development is residual photoreceptor structure that can be rescued.
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This raises the possibility that equivalent neuroprotective strategies may be used to prevent both rod and conephotoreceptor degeneration.
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Finally, CLUL1 was localized to retinal conephotoreceptor cells and a different immunolabeling in light- and dark-adapted retinas was shown.
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A regular hexagonal conephotoreceptor mosaic pattern was seen at 2, 3 and 5° of retinal eccentricity.
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The interactions between opsin and chromophore can be investigated with electrophysiologial recordings in intact amphibian and mouse rod and conephotoreceptor cells.
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Specification of retinal rod photoreceptors is determined by several different transcription factors that activate expression of rod-specific genes and repress expression of conephotoreceptor-specific genes.
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Electroretinography revealed a gradual loss of both rod and conephotoreceptor-mediated function in Stages 2 and 3 of the disease.
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Results: Conephotoreceptor-associated gene expression was elevated in the macula transcription profiles.
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Conephotoreceptors in normal older eyes were shorter than in younger eyes.
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The present study showed that s26 is present in conephotoreceptors.
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Conephotoreceptors mediate our daytime vision and function under bright and rapidly-changing light conditions.
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Conephotoreceptor density was calculated following manual and automated counting.
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Vectors carrying a cone-specific promoter failed to transduce a quantifiable percentage of conephotoreceptors.