Significados de constitutive activation em inglês

NF-kB constitutive activation is a major factor for the apoptosis resistance of melanoma.

Mutations in several domains can lead to agonist-independent, constitutive activation of G protein-coupled receptors.

The constitutive activation of the ALK fusion oncogene renders it vulnerable to therapeutic intervention.

All mutations identified in this study were somatic and caused a constitutive activation of c-KIT.

Most tumors show constitutive activation of the mTOR pathway.

Over 30% of the lines also had constitutive activation of Akt and MAP kinase.

However, the mechanism for this constitutive activation of NF-kappaB has not been elucidated in the tumors.

The modification was specific for glutamine residues in the catalytic core, and triggered their constitutive activation.

Conclusion: Our studies suggest that the constitutive activation of the SERCA pump is detrimental to cardiac function.

Here, we report the effects of constitutive activation of alpha1-adrenergic signaling on connexin phosphorylation and cardiac conduction.

However, there is no data concerning the effect of the constitutive activation of any component of the system.

The various NTRK1 fusions described so far lead to constitutive activation of TRKA kinase activity and are oncogenic.

The constitutive activation of ER stress pathways might contribute to organ pathology and metabolic dysfunction in peroxisomal disorder patients.

These tumors are characterized by constitutive activation of NF-kappaB signals, which supports the data derived from our cell lines.

Mutated primary samples were associated with constitutive activation of the RAS pathway and sensitivity to MEK inhibitors was shown.

We reported recently that the melanoma inducing EGFR-related receptor Xmrk specifically induces constitutive activation of STAT5 in fish melanoma cells.