Dishevelled signaling plays a critical role in the control of cell intercalation during convergentextension in vertebrates.
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The lengthening and narrowing of a field of cells, termed convergentextension, contributes to a variety of morphogenetic processes.
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Planar cell polarity (PCP) signaling controls a number of morphogenetic processes including convergentextension during gastrulation and neural tube formation.
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Background: Animal models of neural tube defects (NTDs) have indicated roles for the Fzd3 gene and the planar cell polarity signaling pathway in convergentextension.