Significados de d-amino acid em inglês

Likewise, incorporation of D-amino acids led to potent inhibitors with a novel mode of binding.

It activates D-amino acid oxidase, which oxidizes D-serine, leading to modulation of the N-methyl-D-aspartate receptor.

Our previous studies have identified synthetic D-amino acid cell adhesion peptides using a combinatorial screening approach.

Because this motif is sufficient for activity, an ShK analogue was designed based on D-amino acids.

The purified enzyme catalyzed the dehydrogenation of various d-amino acids, with d-phenylalanine being the most preferred substrate.

D-Amino acid substitution was employed to search for novel AII antagonists that would also display reduced partial agonist activity.

This D-amino acid cyclic peptide did not adopt a conformation homologous to the NGF C-D loop and was inactive.

N-terminal acetylation or incorporation of D-amino acids in the GPGRAF sequence of this SPC resulted in significant loss of activity.

Overall, these results agree with the innovative therapeutic research in schizophrenia that is aimed at targeting glutamatergic transmission via D-amino acids.

For example, younger animals have lower amounts of these oxidases and consequently higher concentrations of free D-amino acids compared to adult animals.

In the liver and kidneys of the animals, an inverse relationship exists between the occurrence of D-amino acids and these oxidative enzymes.

A specific enzyme induction for these D-amino acid oxidases exists in young rats following ingestion of free D-amino acids by the mother.

Phylogenetic analyses of condensation domains indicated that N-terminal domains and domains that condense L-amino acids and D-amino acids, respectively, form three separate groups.

If the ingested D-amino acids are not metabolized by these enzymes, they will accumulate in the tissues and may provoke serious damage, e.g.

Various studies have reported enhancement in the stability of peptides using methods like chemical modifications, D-amino acid substitution, cyclization, replacement of labile aminos acids, etc.

When a peptide synthesized from D-amino acids (D-4F) was administered orally to LDL receptor-null mice on a Western diet, lesions decreased by 79%.