They looked for breakdown products of a phthalate chemical known as DEHP.
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Our results also indicate a reason for concern about human exposure to DEHP.
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Because of that, he tells parents to avoid buying plastics made with DEHP.
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DEHP is an endocrine disruptor and can pose toxic threats to the reproductive system.
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Mean concentrations of DEHP were combined with individual food consumption data to estimate dietary exposure.
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These doses covered the whole dose-response curve for the demasculinizing effects of DEHP including low-dose effects.
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DEHP exposure explained most of the risk estimates.
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The self-assembled peptides had a stable fibrous morphology and secondary structure after the DEHP degradation assay.
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Foci and tumors appeared earlier in mice given higher dietary levels of DEHP than in those given lower doses.
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At 6 months, the neoplasms in high dose DEHP-exposed mice were significantly larger than those in PB exposed mice.
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Conclusions: Our findings suggest that DEHP exposure may affect body mass change in early life through changes of obesity-related markers.
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Overall, we observed that DEHP adsorbs and potentially embeds itself within all placental lipid bilayers, with varying levels of interaction.
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Intensity of use of products containing DEHP was strongly associated with BPA total concentrations but not with any other phenol.
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Higher doses of DEHP induced histopathological effects on the testes, reduced testis weight, and expression of androgen-regulated genes in the prostate.
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Conclusions: In this population-based case-control study of clinical ADHD, maternal urinary concentrations of DEHP were monotonically associated with increased risk of ADHD.
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PB given continuously for 6 months revealed no initiating activity of DEHP given once by gavage and followed by PB in drinking water.