1
As a result, ATP- dependent efflux of DOX was remarkably inhibited.
2
It may be mediated by overexpression of ATP- dependent efflux pumps or by alterations in survival or apoptotic pathways.
3
P-glycoprotein is believed to function as an energy- dependent efflux pump that is responsible for decreased drug accumulation in multidrug-resistant cells.
4
The multidrug resistance-1 (MDR1) gene encodes an ATP- dependent efflux transporter that is highly expressed in the colon.
5
ARL7 has previously been shown to transport cholesterol to the membrane for ABCA1-associated removal and thus may be integral to the LXR- dependent efflux pathway.