1
The major pathways inhibited include formation of myeloperoxidase- derived and nitric oxide- derived oxidants, species implicated in atherogenesis.
2
Formation of nitric oxide- derived oxidants has been linked to development of atherosclerosis and associated thrombotic complications.
3
We show that an increase in ETC- derived oxidants leads to an increase in mtMetRS oxidation in intact cells.
4
SMase has been shown to increase muscle derived oxidants and decrease skeletal muscle force; however, the sub-cellular site of oxidant production has not been elucidated.