1
Thus, sex- determining region Y-box 2 may play an important role in tumor progression.
2
However, despite heritable segment use, the rearranged complementarity- determining region-H3 repertoires remained highly specific to the individual.
3
Sex- determining region Y-box 2 is proposed to be a key transcription factor in embryonic stem cells.
4
No deletion or mutation was found on the sex- determining region Y. H&E staining revealed seminiferous tubule dysgenesis.
5
The electron density reveals the hapten sitting in a pocket formed by the loops of the complementarity determining region.
6
Eplets are essential parts of so-called structural epitopes that make contact with the 6 complementarity determining regions of an antibody.
7
The aim of the present study was to clarify the clinical role of sex- determining region Y-box 2 expression in ovarian carcinoma.
8
Apart from substitutions within the complementarity determining regions, multiple framework residues including those in protein cores were targets of extensive diversification.
9
Superposition of eight sets of antibody light- and heavy-chain variable domains identified structurally conserved sites within the sequence-variable complementarity determining regions.
10
We observed sex- determining region Y-box 2 expression in 15% of the ovarian carcinoma samples.
11
Here we show that residues in a complementary determining region (CDR) can adopt the same bioactive structures observed in ligands.
12
The survival rate of donor cells was quantified by real-time polymerase chain reaction for the sex- determining region of the Y-chromosome (Sry).
13
Immunohistochemical staining of 540 human ovarian carcinoma samples for sex- determining region Y-box 2 was performed using tissue microarray.
14
Finally, through the analysis of both location and length distribution of SHA indels, we have determined regions of structural plasticity within the antibody protein.
15
Complementarity- determining region 3 length and amino acid designs were based on aggregate frequencies of all V(H) and V(k) sequences in the data set.
16
The known roles of sex- determining region Y-box 2 in development and cell differentiation suggest that it is relevant to the aberrant growth of tumor cells.