A newly formed high-density lipoprotein particle; consists of a phospholipid bilayer surrounded by two or more APOA1 molecules.
1Over 25 years of study have produced two general models of apoA-I structure in discoidal HDL complexes.
2We show that these two different sizes of discoidal HDL particles display different stability and phospholipid-binding activity.
3We report here a study of the self-assembly of discoidal HDL particles using coarse-grained (CG) molecular dynamics.
4One of the major problems for high-resolution structural studies of discoidal HDL is the difficulty in obtaining pure and, foremost, homogenous sample.
5In terms of discoidal HDL particles, there has been a debate as to the orientation of the apoA-I alpha-helices around the disc edge.
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