Several recent studies have shown that caffeine potentiates the reinforcing, discriminativestimulus, and motor activating effects of cocaine in rats.
2
Partial generalization could conceivably result from low efficacy actions at the receptor mediating the discriminativestimulus effects of the training drug.
3
Taken together, these results indicate that adaptive changes in LSD-stimulated serotonin receptor signaling may mediate tolerance to the discriminativestimulus effects of LSD.
4
Moreover, it did not alter the discriminativestimulus effects of anandamide in FAAH-deficient mice or Δ-tetrahydrocannabinol in wild-type mice in the drug discrimination paradigm.