We identified candidate pools of epigenetic compounds that improve skeletal muscle structure in dmd mutant zebrafish.
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Results: We performed a novel chemical-combination screen of a library of epigenetic compounds using the zebrafish dmd model.
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A commercially available library of epigenetic small molecules was used to treat embryonic-larval stages of dmd mutant zebrafish.
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We used a quantitative muscle birefringence assay in order to assess and compare the effects of small-molecule treatments on dmd mutant zebrafish skeletal muscle structure.
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Through optogenetic and pharmacological approaches, we show that the sensory and muscle cell characteristics controlled by dmd-3 and mab-23 are crucial for circuit function.
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Methods: Eight families at risk for DMD were recruited for this study.
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DMD segment supplies newspaper and magazines to airlines and provides inflight services.
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The mdx diaphragm muscle closely mimics the pathophysiological changes in DMD muscles.
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Fifty five articles featured a questionnaire assessing quality of life in DMD.
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The possibility to treat DMD through cell therapy has been widely investigated.
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It is focused on the development of its disease-modifying DMD drug candidates.
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Methods: Thirty-one DMD and 11 healthy control participants were prospectively enrolled.
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A new trial, FOR-DMD, aims to address this gap in knowledge.
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Other attempts to develop a treatment for DMD have also been thwarted recently.
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The mdx mouse is a widely used animal model of DMD.
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The Company operates in three segments: Smiths News, DMD and Tuffnells.