Usage of "germline variant"

russo

Inherited genetic variation.

Uso de germline variant em inglês

Non-tumoural tissue was sequenced to exclude germline variants in cases where available. 
 Pubmed 

Hypothesis: Germline variants of double-strand break repair genes are markers of DTC risk. 
 Pubmed 

Other possible AURKA germline variants were screened by sequencing 10 of the familial cases. 
 Pubmed 

Background: During the process of tumor profiling, there is the potential to detect germline variants. 
 Pubmed 

However, the putative contribution of common NOS3 germline variants to breast cancer risk remained unknown. 
 Pubmed 

Objective: To determine the risks of breast cancer associated with germline variants in cancer predisposition genes. 
 Pubmed 

Additionally, nine FAP-PTC patients had rare germline variants in genes that were previously associated with thyroid carcinoma. 
 Pubmed 

Two ETV6 germline variants gave rise to both AML and ALL, with lineage-specific genetic lesions in the leukemia genomes. 
 Pubmed 

However, the relevance of germline variants in other genes from multigene hereditary cancer testing panels is not well defined. 
 Pubmed 

We identified two germline variants that are predictive of poor patient outcomes by Cox regression, controlling for eleven covariates. 
 Pubmed 

Data were processed through an analytical pipeline to search for rare germline variants in known or novel CRC predisposing genes. 
 Pubmed 

Second is a case illustrating the potential for tumor sequencing to suggest germline variants associated with a hereditary cancer syndrome. 
 Pubmed 

In this study, we investigated the contribution of rare germline variants to risk of malignant pediatric astrocytoma on a population level. 
 Pubmed 

Results: We discovered 72 rare deleterious germline variants in 56 genes shared by all three individuals. 
 Pubmed 

Previous studies have mostly focused on the roles of somatic mutations in tumorigenesis, but how germline variants act is largely unknown. 
 Pubmed 

Results: In total, 32 germline variants in 23 genes were identified and confirmed by Sanger sequencing. 
 Pubmed 

Translations for germline variant

russo

Significados de germline variant em inglês