1 There were no treatment-related deaths or grade 4 toxicity in either group.
2 Notably there were no late grade 4 toxicities and no treatment-related deaths.
3 Aggressive administration of loperamide also reduced the incidence of grade 4 diarrhea.
4 During the second course, two out of four patients presented grade 4 thrombocytopenia.
5 Results: Toxicity was low in both groups, with no CTC grade 4 toxicity.
6 There were no grade 4 treatment-related adverse events or treatment-related deaths.
7 There were no grade 4 events, and no diarrhea-related treatment discontinuations.
8 Two patients had grade 4 neutropenia with sepsis necessitating treatment withdrawal.
9 Individual pupils pass a GCSE if they get a grade 4 or above.
10 All three experienced grade 4 diarrhea, two also had neutropenic sepsis.
11 Toxicity was mild, with only one episode of grade 4 neutropenia and constipation.
12 No grade 4 toxic effects or treatment-associated deaths were observed.
13 No transverse myelitis or late toxicities of grade 4 or greater have been observed.
14 No grade 4 or higher toxicities were observed during the treatment and follow-up periods.
15 There were no grade 4 toxicities and only one patient suffered from febrile neutropenia.
16 One patient met protocol-defined criteria for unacceptable toxicity ( grade 4 hypoxia).
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