The former is induced by hypercytokinemia and hyperendotoxemia, and the latter is caused by cell cycle arrest.
2
These results suggest the usefulness of JTE-607 in therapeutic applications for patients with hypercytokinemia and aggressive AML cell proliferation.
3
Ischemic-like lesions result from hypovolemia and unusual coagulation, whereas PRES-like lesions are caused by direct heat and vasogenic edema due to hypercytokinemia.