It is a devastating and intractabledisease with a poor outcome.
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A conditional logistic regression analysis confirmed an independent effect of age at diagnosis on ileal disease and surgery for intractabledisease.
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Our work identifies and validates USP18 as a pancreatic cancer oncogene and provides a potential druggable target for this intractabledisease.
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The findings hold great promise for the development of new treatments for intractablediseases.
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A number of these early lethal intractablediseases also present devastating irreversible pathology at birth or soon after.
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Aside from representing remarkable science, these breakthroughs have the potential to deliver powerful new treatments for formerly intractablediseases.
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Pancreatic cancer is one of the intractablediseases and an effective therapeutic strategy is required to improve the prognosis.
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Intractablediseases such as cancer are associated with breakdown in multiple individual functions, which conspire to create unhealthy phenotype-combinations.
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About Arrowhead Pharmaceuticals Inc Arrowhead Pharmaceuticals, Inc., formerly Arrowhead Research Corporation, develops medicines that treat intractablediseases by silencing the genes that cause them.