Ainda não temos significados para "limit toxicity".
1Plasma haem can cause endothelial injury and organ dysfunction, and is normally scavenged by haemopexin to limit toxicity.
2Future work will continue to optimize the bladder-sparing regimen while limiting toxicity.
3The primary end point was safety, including the incidence of dose- limiting toxicities.
4There were no dose limiting toxicities, therefore the MTD was not defined.
5Overall, no dose- limiting toxicities or safety signals were observed in the study.
6No dose- limiting toxicities were observed despite escalation to the highest dose level.
7Dose- limiting toxicities were primarily enhanced epithelial reactions, but febrile neutropenia also occurred.
8With the exception of chemical peritonitis-induced adhesions, no limiting toxicity was observed.
9The main dose limiting toxicity was myelosuppression which seemed to be cumulative.
10Dose- limiting toxicities were observed for one patient at the 400 mg dose.
11No dose- limiting toxicities were identified, and maximum tolerated dose was not reached.
12No dose- limiting toxicity was observed and the maximum-tolerated dose was not reached.
13Thrombocytopenia was reported as a dose- limiting toxicity for both 254-S and carboplatin.
14Dose- limiting toxicities were defined as grade 3 esophageal, cardiac, or pulmonary toxicity.
15Results: All patients tolerated the single-fraction SBRT well without developing a dose- limiting toxicity.
16No dose- limiting toxicities and treatment related severe adverse events were observed.