The presence of ApoE ɛ4 increases significantly the risk of conversion.

We conducted a screen to identify variants associated with the age of onset of Alzheimer's disease in APOE ɛ4 carriers.

The G allele of rs1884444 polymorphism is significantly associated with a higher risk of AD in APOE ɛ4 carriers.

Conclusion: Our study finds similar effects of the ɛ4-linked haplotypes defined by rs769449 on AD as compared to ɛ3 in both AA and EU.