Concentration of vapor in the lungs needed to prevent motor response in 50% of subjects in response to surgical stimulus; used to compare the potency of anesthetic vapors.
However, the isoflurane concentrations above 1 minimumalveolarconcentration (MAC) have been associated with reduced neuronal survival and impaired functional outcome.
2
Previous studies have shown that antagonism of glutamate at the NMDA receptor reduces the minimumalveolarconcentration (MAC) for volatile anesthetics.
3
Anaesthesia was maintained with up to 50% nitrous oxide and up to one minimumalveolarconcentration of sevoflurane until the umbilical cord was clamped.
4
Background: Minimumalveolarconcentration (MAC) and MAC-awake decrease with age.