Myeloid progenitors lose their potential to generate neutrophils when they adopt the mononuclearphagocyte lineage.
2
The daily clearance of physiologically dying cells is performed safely mainly by cells in the mononuclearphagocyte system.
3
Cells of the mononuclearphagocyte system, primarily macrophages, were identified as the early and sustained targets of EBO virus.
4
Multiparameter flow cytometry was used to identify mononuclearphagocyte populations among cells labeled by each route of antibody delivery.
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Because promoter-distal enhancers are key to cell fate decisions, we analyzed enhancer landscapes during mononuclearphagocyte development in vivo.
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CSF-1 is a growth factor that selectively promotes the proliferation, survival, and differentiation of cells of the mononuclearphagocyte series.
7
Such polymers shield the particle surface and thereby reduce opsonization by blood proteins and uptake by macrophages of the mononuclearphagocyte system.
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We found that Sall1 was expressed by microglia but not by other members of the mononuclearphagocyte system or by other CNS-resident cells.
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Thus, IRF8 not only bestows monocyte and DC differentiation potential upon mononuclearphagocyte progenitors but also restrains these progenitors from differentiating into neutrophils.
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This review details current understanding of the heterogeneity of apoptotic cell uptake by different members of the mononuclearphagocyte family in humans and mice.
11
Conversely, IRAK-M loss-of-function mutations or transient exposure to bacterial DNA may drive persistent inflammatory mononuclearphagocyte infiltrates, which impair kidney regeneration and promote CKD.
12
Our results illustrate the dynamic process by which key transcription factors regulate enhancer formation and, therefore, direct future gene expression to achieve mononuclearphagocyte development.
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Indium 111-labeled cells were present in all tissue associated with the reticuloendothelial system or mononuclearphagocyte system at 24 hours.
14
Trials in patients with cancer, leprosy, and the acquired immunodeficiency syndrome (AIDS) have shown that interferon-gamma can activate the mononuclearphagocyte in humans.
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The mononuclearphagocyte system (MPS) is a family of cells of related function that includes bone marrow progenitors, blood monocytes and resident tissue macrophages.
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Recruited mononuclearphagocytes with low levels of SP-A and SP-D mediated this effect.